TuranA,BabazadeR,KurzA,etal.ClonidineDoesNotReducePainorOpioidConsumptionAfterNoncardiacSurgery[J].AnesthAnalg,,(3):-
Abstract
BACKGROUND:Clonidineisanα2-adrenoceptoragonist,whichhasanalgesicproperties.However,theanalgesicefficacyofperioperativeclonidineremainsunclear.We,therefore,testedthehypothesisthatclonidinereducesbothpainscoresandcumulativeopioidconsumptionduringtheinitial72hoursafternoncardiacsurgery.
METHODS:Sixhundredtwenty-fourpatientsundergoingelectivenoncardiacsurgeryundergeneralandspinalanesthesiawereincludedinthissubstudyofthePeriOperativeISchemiaEvaluation-2trial.Patientswererandomlyassignedto0.2mgoralclonidineorplacebo2to4hoursbeforesurgery,followedby0.2mg/dtransdermalclonidinepatchorplacebopatch,whichwasmaintaineduntil72hoursaftersurgery.Postoperativepainscoresandopioidconsumptionwereassessedfor72hoursaftersurgery.
RESULTS:Clonidinehadnoeffectonopioidconsumption中科医院专家北京哪家医院治疗白癜风
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